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Pharmacology: Pharmacodynamics: Mechanism of Action: Quetiapine fumarate is a dibenzothiazepine atypical antipsychotic. It is reported to have affinity for serotonin (5-HT2), histaminergic (H1), and adrenergic (α1 and α2) receptors as well as dopamine D2 receptors.
Pharmacokinetics: Quetiapine is well absorbed following oral administration and widely distributed throughout the body. Peak plasma concentrations are reached in about 1.5 hours. It is about 83% bound to plasma proteins. Quetiapine is extensively metabolized in the liver by sulfoxidation mediated mainly by the cytochrome P450 isoenzyme CYP3A4 and by oxidation. It is excreted mainly as inactive metabolites, about 73% of a dose appearing in the urine and about 20% in the feces. The elimination half-life has been reported to be about 6 to 7 hours.
